Human Insulin Receptor Substrate-2 (IRS-2) Is a Primary Progesterone Response Gene
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منابع مشابه
Insulin Receptor Substrate-2 (IRS-2): A Novel Hypoxia-Responsive Gene in Breast Cancer: A Dissertation
Breast cancer is the most common malignancy among women in the U.S. While many successful treatments exist for primary breast cancer, very few are available for patients with metastatic disease. The purpose of this study was to understand the role of Insulin Receptor Subtrate-2 (IRS-2) in breast cancer metastasis. IRS-2 belongs to the IRS family of cytoplasmic adaptor proteins that mediate sign...
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To investigate the role of insulin receptor substrate 1 (IRS-1) and IRS-2, the two ubiquitously expressed IRS proteins, in adipocyte differentiation, we established embryonic fibroblast cells with four different genotypes, i.e., wild-type, IRS-1 deficient (IRS-1(-/-)), IRS-2 deficient (IRS-2(-/-)), and IRS-1 IRS-2 double deficient (IRS-1(-/-) IRS-2(-/-)), from mouse embryos of the corresponding...
متن کاملInsulin-Receptor Substrate-2 (IRS-2) Is Required for Maintaining Glucokinase and Glucokinase Regulatory Protein Expression in Mouse Liver
Insulin receptor substrate (IRS) proteins play important roles in hepatic nutrient homeostasis. Since glucokinase (GK) and glucokinase regulatory protein (GKRP) function as key glucose sensors, we have investigated the expression of GK and GKRP in liver of Irs-2 deficient mice and Irs2(-/-) mice where Irs2 was reintroduced specifically into pancreatic β-cells [RIP-Irs-2/IRS-2(-/-)]. We observed...
متن کاملInsulin receptor substrate-2--a new candidate gene for NIDDM?
The pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM) includes the development of insulin resistance and, at a later stage, impairment of b-cell response. In the past few years, different elements, including the proto-oncogene, Shc, and the insulin receptor substrate (IRS) proteins, have been found to have important roles in the insulin signaling network. Whithers et al. (1) have ...
متن کاملPolymorphisms in the insulin receptor substrate-1 (IRS-1) gene and the insulin receptor substrate-2 (IRS-2) gene influence glucose homeostasis and body mass index in women with polycystic ovary syndrome and non-hyperandrogenic controls.
BACKGROUND We aimed to evaluate the influence of the Gly972Arg variant of the insulin receptor substrate-1 gene (IRS-1) and the Gly1057Asp variant in IRS-2 on insulin resistance and glucose tolerance in women with polycystic ovary syndrome (PCOS) and healthy controls. METHODS Genotypes, allelic frequencies, indexes of insulin resistance, glucose tolerance and hormone profiles were studied in ...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 1999
ISSN: 0888-8809,1944-9917
DOI: 10.1210/mend.13.3.0256